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Enterprise AI Comparison

Microsoft Copilot vs ChatGPT Enterprise

A feature-by-feature comparison for CIOs choosing between Microsoft 365 Copilot and ChatGPT Enterprise. Security, compliance, cost, and integration analysis.

Microsoft 365 Copilot

$30/user/month

Best for organizations deeply invested in the Microsoft 365 ecosystem. Native integration with Word, Excel, PowerPoint, Teams, Outlook, and SharePoint.

Best For:

  • Document creation and editing workflows
  • Email management and meeting summaries
  • Data analysis within Excel
  • Organizations needing FedRAMP compliance
  • Environments with existing Microsoft security investments

ChatGPT Enterprise

~$60-80/user/month

Best for organizations needing a versatile AI assistant for research, coding, creative work, and general knowledge tasks across any platform.

Best For:

  • General research and knowledge queries
  • Software development and code generation
  • Creative content and image generation
  • Cross-platform AI assistance
  • Organizations not on Microsoft 365

Feature Comparison

Head-to-Head Feature Analysis

16 critical enterprise features compared across security, compliance, integration, and capability dimensions.

Feature

M365 Copilot

ChatGPT Enterprise

Notes

Microsoft 365 Integration

Native

Limited

Word, Excel, PowerPoint, Teams, Outlook

SharePoint & OneDrive Access

Native

No

Searches your organizational data

Teams Meeting Summaries

Native

No

Real-time transcription and action items

Email Drafting in Outlook

Native

No

Context-aware email composition

Data Analysis in Excel

Native

Upload Only

Direct spreadsheet manipulation

Sensitivity Label Enforcement

Native

No

Respects Microsoft Purview labels

DLP Policy Integration

Native

No

Inherits existing DLP rules

General Knowledge & Research

Good

Excellent

Broader training data in ChatGPT

Code Generation

Good

Excellent

ChatGPT has stronger coding capabilities

Image Generation

Basic

Excellent

DALL-E integration in ChatGPT

Custom GPTs / Agents

Copilot Studio

Custom GPTs

Both offer customization platforms

Audit Logging

Native

Basic

Unified audit log in Microsoft 365

Data Residency Controls

Native

Limited

Inherits M365 geo configuration

SOC 2 Compliance

Yes

Yes

Both maintain SOC 2 certification

HIPAA BAA Available

Yes

Yes

Both offer Business Associate Agreements

FedRAMP Authorization

Yes

No

GCC/GCC High for Copilot

Cost Analysis

3-Year TCO for 1,000 Users

Microsoft 365 Copilot

License cost

$30/user/month

Annual cost (1,000 users)

$360,000

3-year total

$1,080,000

Prerequisite

M365 E3/E5 required

Implementation

$50K-$150K (one-time)

ChatGPT Enterprise

License cost

~$60-80/user/month

Annual cost (1,000 users)

$720,000-$960,000

3-year total

$2,160,000-$2,880,000

Prerequisite

None

Implementation

$20K-$50K (one-time)

Our Recommendation

For organizations already on Microsoft 365 E3/E5, Copilot delivers 40-60% lower TCO and significantly deeper integration with your existing workflows. The security posture advantage alone justifies the selection for regulated industries. Consider ChatGPT Enterprise as a complement for developer teams and research functions where cross-platform flexibility is prioritized over M365 integration.

Security & Compliance

Enterprise Security Comparison

Data Handling

MICROSOFT 365 COPILOT

Data stays within your M365 tenant boundary. No data used for model training. Inherits your existing DLP policies and sensitivity labels.

CHATGPT ENTERPRISE

Data isolated per organization. No data used for model training. Requires separate security configuration independent of your existing tools.

Compliance Certifications

MICROSOFT 365 COPILOT

SOC 2, ISO 27001, HIPAA BAA, FedRAMP (GCC/GCC High), GDPR, FERPA, and 80+ compliance certifications inherited from Microsoft 365.

CHATGPT ENTERPRISE

SOC 2, HIPAA BAA, GDPR. Growing certification portfolio but fewer than Microsoft 365. No FedRAMP authorization.

Audit & Monitoring

MICROSOFT 365 COPILOT

Full integration with Microsoft 365 Unified Audit Log, Microsoft Purview, and Defender for Cloud Apps. Native eDiscovery support.

CHATGPT ENTERPRISE

Admin console with usage analytics. API-based log export. No native integration with enterprise SIEM tools.

Frequently Asked Questions

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